Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species

In this study, the anti-cholinesterase activities of different extracts Achillea lycaonica, A. vermicularis and nobilis L. subsp. neilreichii (Kerner) Formanek species were examined then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, Pb) plants analysed by ICP-MS. The pharmacokinetic properties phenolic compounds these previously analyzed us ADME-Tox (absorption, distribution, metabolism, excretion, toxicity) profiles we identified in study estimated. According to data obtained, it was determined that all three showed high acetyl-cholinesterase inhibition activity. concentration lower than declared WHO, except for lycaonica. It As metals lycaonica exceeded limit values WHO. ADMET estimates, is thought toxic are not high, therefore use does pose any health risk but A should be used carefully due heavy metals.